HEART STUDIES
Sung (2014) – Myocardial Protection in donor heart preservation: a comparison between Bretschneider’s HTK and Cold blood cardioplegia
This study compares the efficacy of myocardial protection in a single dose of Custodiol HTK with repeated doses of cold blood cardioplegia. This study concluded that a single dose of Bretschneider’s HTK solution could effectively reduce pumping time and afford similar myocardial protection compared with repeated doses of CBC in the preservation of donated hearts.
Ackerman (2002) – Celsior versus Custodiol: early postischemic recovery after cardioplegia and ischemia at 5°C
This study compares Celsior and Custodiol preservation solutions in canine hearts in regards to the postichemic recovery of the organs. It found that there was no advantage of cardioplegia with Celsior over cardioplegia with Custodiol.
Plestis (2016) – Minimally Invasive Aortic Surgery With Emphasis On Technical Aspects, Extracorporeal Circulation Management And Cardioplegic Technique
Study by Dr. Konstandinos A Plestis, Chief of Cardiothoracic and Vascular Surgery, Thomas Jefferson University
LIVER STUDIES
Nguyen (2015) – Biliary Reconstruction in Pediatric Liver Transplantation: A Case Report of Biliary Complications and Review of Literature
With the advent of segmental liver allografts from liver donors, reduced-size cadaveric allografts, and split cadaveric allografts, pediatric pre-transplantation patient mortality has reduced. However, this expansion of the donor pool for size-appropriate allografts for patients with end-stage liver disease has led to an increased incidence of biliary complications.
Heidenhain (2009) – Incidence of and risk factors for ischemic-type biliary lesions following orthotopic liver transplantation
This large retrospective study showed that there is a significantly increased risk of ischemic-type biliary lesions when using UW compared to HTK. From this single center study they concluded that they would exclusively use HTK in
Welling (2008) – Biliary Complications following liver transplantation in the model for end-stage liver disease era: Effect of donor recipient and technical factors
This single center retrospective study analyzed the effects of the donors, recipients, as well as the technical factors involved in liver transplantation and their effect on biliary complications. They found that the most important variables to reduce biliary complications are decreased warm ischemic times, use of HTK, and the use of a stent.
PANCREAS STUDIES
Becker (2007) – Pancreas transplantation with HTK solution and UW solution: Is there a difference?
This study compares the efficacy of HTK and UW in preservation of pancreas grafts in regards to patient and graft survival as well as some of the biomarkers of successful transplantation. They found that HTK is clinically comparable to UW, and that both solutions are safe for pancreas preservation.
Paushter (2013) – HTK and UW solution demonstrate equal effectiveness in the preservation of human pancreata intended for islet isolation: a large scale, single center experience
This study compared the ability of HTK and UW to preserve pancreas grafts for islet transplantation. They found equivalent results between HTK and UW for preservation of pancreata.
Schneeberger (2008) – A prospective randomized multicenter trial comparing HTK versus UW perfusion solution in clinical pancreas transplantation
This study found that in the clinical setting with cold ischemic times averaging 10 hours, HTK and UW solutions appear to be equivalent in preserving pancreata for transplantation.
Reddy – Pancreas Transplant using HTK – Is it a Cautionary Tale?
This abstract presented at the American Transplant Congress in 2009, found that at their center there was no difference in pancreas transplant outcomes or biomarkers between HTK and UW preservation solutions with cold ischemic times up to 15 hours.
KIDNEY STUDIES
Agarwal (2006) – Comparison of HTK solution and UW solution in prolonged cold preservation of kidney allografts
This study compares Custodiol HTK and UW preservation solutions in kidney allografts with prolonged cold ischemic times greater than 16 hours. They found that HTK is at least comparable to UW in the preservation of kidney allografts even with prolonged cold ischemic times. Even with ischemic times longer than 24 hours HTK was not inferior to UW in organ preservation.
DeBoer (1999) – Eurotransplant randomized multicenter kidney graft preservation study comparing HTK with UW and Euro-Collins
This study compared HTK, UW and Euro-Collins solution in the preservation of kidney grafts with regards to the initial graft function as well as the long term graft survival. The study concluded that both HTK and UW were superior in comparison to EC solution, and that HTK is comparable to UW in preserving kidneys from heart beating donors.
Lynch (2008) – Comparison of HTK and UW preservation in renal transplantati
This large retrospective single center comparison between HTK and UW transplant solutions in kidney transplantation compares multiple factors including patient and graft survival as well as delayed graft function. It concludes that although there was increased incidence of DGF with HTK, there was similar efficacy between HTK and UW in terms of patient and graft survival.
This abstract presented at the ATC in 2012 retrospectively reviewed living donor kidney transplants comparing HTK and UW to LR solutions. They found that HTK was superior to LR in preventing DGF, and that both HTK and UW are more cost effective than LR in live donor kidney transplantation.