Pancreas Transplantation with Custodiol® HTK

• HTK is comparable to UW. Both solutions have been shown to be safe for Pancreas Transplantation.¹¹
• The key to successful pancreas transplantation is a safe organ procurement and preservation technique.¹¹

• In the postoperative course, both serum pancreatic enzymes decrease rapidly from day 2 with no further significant differences between the two groups of patients.¹¹
• … especially in cases of prolonged donor operations, the flush volume should be reduced after the initial rapid flush in order to cool down the organs.¹¹
• A lack of technical procurement skills might raise the risk of graft pancreatitis.¹¹

HTK preservation showed equal patient and graft survival rates compared to UW preservation in clinical pancreas transplantation.

Organ Preservation with Histidine-Tryptophane Ketoglutarate Solution in Clinical Pancreas Transplantation⁷

There were no episodes of primary graft function

HTK is safe for pancreas preservation with results comparable to UW. In this study, Custodiol® HTK was found:

• …reliable preservation of pancreas allografts in terms of patient and graft survival and early graft function.
• All patients are off insulin with excellent glucose control by discharge.
• Results consistent with University of Pittsburgh¹² and Michigan¹³ groups in showing no significant difference in early clinical outcomes between UW and HTK cold preservation.
• Serum fasting blood glucose and serial amylase remained comparable at all intervals post-transplantation to those of a historical UW cohort.

References for this page