HTK was associated with a significant risk reduction on the incidence of DGF.⁵

• Graft survival did not significantly differ by preservation solution but in living donor patients, HTK showed a trend toward improved long-term graft survival over UW solution.⁵

 

• …with cold ischemia times over 24 hours, there is not detriment associated with HTK use.⁵
• Despite a numerically higher incidence of DGF in the HTK group, Cox multivariable regression analysis shows a reduction in DGF with HTK preservation. This may reflect an era effect, where the HTK variable represents not only preservation solution, but a reference to year of operation.⁵

Prolonged Cold Preservation of Kidney Allografts⁶

• The only significant variable in the multivariate analysis was the preservation solution, with UW having a greater tendency towards DGF.⁶
• The patient demographics revealed no significant difference between the two groups, however there was longer CIT and WIT in the HTK group.⁶
• There was a trend toward improved graft survival in HTK.⁶
• To date, HTK Solution is at least comparable to UW for cold preservation of renal allografts. We report that with prolonged cold ischemia times (greater than 24 hr). HTK is not inferior to UW as previously suggested by other authors and may in fact provide better protection for the prevention of delayed graft function compared to UW solution.⁶

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